Surrounded by a certain mystique, Growth Hormone (GH) has often been credited with providing near magical effects, with everyone from bodybuilders to life extensionists singing its praise. However, its high price tag and an unreliable blackmarket have established it as somewhat of a novelty drug, cementing its status as a product reserved for the affluent and bodybuilding elite.
Although unaffordable to most, the majority of competitive bodybuilders view growth hormone as a necessary stepping stone in their evolutionary journey toward physical perfection. This has caused some to make unreasonable concessions, even to the point of financial irresponsibility. Others simply go without, hoping to one day make it a part of their program. Unfortunately, using just 6-7 IU per day will cost the average individual about $1000 per month—enough to make a decent car payment.
We all know bodybuilding is a really cool sport, but it can also be damn expensive, with lots of people never coming anywhere close to achieving their full potential simply because they can’t afford to live the lifestyle necessary to make it happen. Food, gym membership fees, supplementation, contest expenses, and sometimes even things like physical therapy, chiropractic care, and deep tissue massage may be required in order for one to be their best…and this doesn’t even include drugs, which can be a massive expense all by itself!
GH PEP 2.0 (MK-677) Vs GH Peptides:
While growth hormone releasing agents are not yet capable of replacing very large doses of exogenous GH, when using the right compounds at the right dosages, we have seen lab work from individuals whose IGF-1 levels (the most accurate method of determining GH levels within the body) reached the equivalent of at least an 8 IU daily dose of growth hormone. Furthermore, these results were achieved at a fraction of the cost of exogenous GH. Of all the various GH elevating drugs at our disposal, I find GH PEP 2.0 (MK-677) to be the most fascinating. There are several things which set GH PEP 2.0 (MK-677) apart from other GH releasers, but first, what exactly is GH PEP 2.0 (MK-677)
Technically, GH PEP 2.0 (MK-677) is not a GH peptide at all, but a selective androgen receptor modulator (S.A.R.M). Most people, when they think of S.A.R.M’s, tend to think of steroid-like drugs such as STANAZINE 2.0 (S4), but S.A.R.M’s aren’t limited to steroid mimetics alone. Rather, they can have a wide range of effects in the body, serving as fat burners CARDIO SHRED 2.0 (CARDARINE OR GW0742), muscle builders PHYSIQUE 400 2.0 (LGD-4033), and in the case of MK-677, GH elevating agents.
One of the most basic differences between GH peptides and GH PEP 2.0 (MK-677) is its oral bioavailability. While most of those who use AAS and other bodybuilding drugs aren’t really bothered by needles, it’s always nice when a drug can be swallowed rather than pinned. It’s just easier and more convenient. Obviously, for the needle averse, this would be viewed as a significant benefit.
In addition, it only needs to be taken once per day, due to its long active-life within the body. Among the various GH peptides, only GH PEP 2.0 (MK-677) has the ability to be dosed this infrequently, while the majority must be used 3-5X per day in order to keep GH levels elevated for a decent period of time. Although short duration GH peptides can certainly be effective, even die-hard bodybuilders have to admit this gets to be a pain in the ass, especially when using compounds that need to be timed around meals (elevated blood glucose levels can impair the effectiveness of some GH peptides). With GH PEP 2.0 (MK-677), a once per day oral dose delivers maximum effects, with additional doses providing no further benefit.
As some of you might know, many GH peptides have been demonstrated to increase both cortisol and prolactin levels, neither of which is desirable. But in all fairness, these two hormones are often impacted to only a small degree, with only a couple GH peptides resulting in elevations outside the normal range. Although anywhere within normal is usually considered acceptable and unlikely to cause any issues, it would still be better if they did not increase them at all.
During the first week of treatment, GH PEP 2.0 (MK-677) causes a slight elevation in both cortisol and prolactin (still within the normal range), but after one week of use, levels revert back to baseline. In terms of unwanted hormonal manipulation, this makes GH PEP 2.0 (MK-677) a cleaner GH releasing agent than other GH peptides, Ipamorelin aside.
One of the most well known effects of several GH peptides is their ability to stimulate the appetite. As ghrelin mimetics, drugs like GHRP-2 and GHRP-6 can have a profound impact on hunger in most individuals. In this capacity MK-677 is no different. Similar to GHRP-2 and GHRP-6, MK-677 provides a distinct increase in hunger shortly after administration. However, unlike the above mentioned compounds, this effect is much longer-lasting, sticking around for between 12-24 hours in most cases.
When discussing IGF-1 within the context of muscle growth, most tend to focus on the level of this hormone in the bloodstream, while paying little to no attention to those factors which influence the ability of IGF-1 to do its job. One of these is IGF-1 binding protein 3, or IGFBP-3, for short. While low dosages of GH PEP 2.0 (MK-677) (5 mg/day) do not increase levels of this protein, normal dosages (25 mg/day and above) do. For many of you reading this, your initial reaction may be to think of this as a negative trait, due to misconceptions surrounding the role of sex hormone binding globulin (SHBG) in testosterone metabolism, but the truth is that elevations of IGFBP-3 (as well as SHBG, for that matter) are a good thing.
Let’s use testosterone as an example. Once testosterone has entered the bloodstream, it resides in one of two forms—in either a free or bound state. Free testosterone circulates as is, while bound testosterone is testosterone which has been bound to SHBG. For decades, most people thought, even the medical community, that free testosterone was all that mattered, as bound testosterone was believed to be unusable by the body; held hostage by SHBG. We now know we were wrong, as SHBG is not the enemy after all, but functions as transporter protein, helping to usher testosterone to the receptor site where it can then perform its actions.
In the same way, IGFBP-3 is the main carrier of IGF-1, but IGFBP-3 is more than just a transporter. It also helps prolong the life of IGF-1 in the body. In other words, the more IGFBP-3 present, the better. So, GH PEP 2.0 (MK-677) not only increases growth hormone and IGF-1 levels, but also IGFBP-3, further potentiating the positive effects of IGF-1 on muscle growth.
For those of you who have difficulty sleeping, or don’t feel as rested as you should when you wake up in the morning, GH PEP 2.0 (MK-677) may be able to help. GH PEP 2.0 (MK-677) has been shown to increase the amount of time spent in stage IV sleep by 50%, while also increasing REM sleep by 20%.
With so many benefits and its relative affordability, it is not hard to see why GH PEP 2.0 (MK-677) has exploded in popularity over the last year. For those of you who want to experience the benefits of elevated GH levels, but don’t have the cash, or don’t want to take the risk with blackmarket GH, GH PEP 2.0 (MK-677) is a viable, clinically proven alternative that is both easy and legal to use.